Tofacitinib Citrate in china 540737-29-9 Fast delivery Hot sale CAS NO.540737-29-9

Tofacitinib Citrate in china 540737-29-9 Fast delivery Hot sale 

Tofatinib is an oral JAKs inhibitor with half the effective concentrations (IC50) of in vitro inhibition kinase JAK1, JAK2 and JAK3, and the ability to selectively inhibit JAK3 in cell experiments is more than 10 times higher than that of JAK2. Tofatinib can be combined with the co-chain of recep γ tors such as cytokines IL-2, 4, 7, 9 necessary to activate T cells. The drug has shown effective in mouse animal models of heart transplants, demonstrating the vital role of T-cells in transplant rejection.

Based on 4-chlorine-7H-gazprop and the starting material of 2,3-d , the amino protection reaction with toluene sulfonyl chloride (2) was obtained with 4-chlor-7-toluene sulfonylazepine and 2,3-d , compound 3 and (3R, 3R, 4R)-1-Pyri-4-Methyl-3-Methamine-Pyridine (4) has a substitution reaction, resulting in an N-(3R, 4R)-1-Pyri-4-Methyl-3-base-N-methyl-7-toluene sulfonylchidine 2,3-d) saccharine-4-amine (5), compound 5 by alkali hydrolysis to obtain N-(3R, 4R)-1-pyri-4-methyl-methyl-base-N-methyl-7H-gynaeco Nico-4-amine (6), compound 6 is protected by catalytic hydrogenation reaction deactivity to obtain N-(3R, 4R)-4-methyl-methyl-base-N-methyl-7H-gynaecogen and 2,3-d- saccharine-4-amine (7), Compound 7 reacts with ethyl cyanate to produce tofatinib,

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