Tofacitinib Citrate factory Buy CAS 540737-29-9 wholesaler CAS NO.540737-29-9

Tofacitinib Citrate factory Buy 540737-29-9 wholesaler 

Potent, cell-permeable inhibitor of JAK1/2/3 (in cell-free assays JAK1 IC₅₀ = 112 nM; JAK2 IC₅₀ = 20 nM; JAK3 IC₅₀ = 1 nM). Exhibits immunosuppressive, anti-inflammatory, and antiviral activities. Inhibits production of inflammatory cytokines, Th2 cell differentiation, Th17 cell differentiation, and activation of STAT1 in vitro. Prevents induction of T-bet and generation of Th1 cells. Inhibits HIV replication and reactivation of latent HIV-1 in cell models.

Tofatinib works by regulating body fluid immunity. The drug inhibits the body fluid immune response by effectively inhibiting antigen-specific antibody responses, which in turn affect the formation of germinalcenter (GC), inhibit the differentiation and proliferation of B and T cells and Ig class conversion, and, to a certain extent, reduce the total serum IgG level.

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