Tofacitinib Citrate Manufacturers 540737-29-9 good producer global CAS NO.540737-29-9

Tofacitinib Citrate Manufacturers 540737-29-9 good producer global 

Tofatinib acts on human mononuclear cells and membrane-sliding cells and inhibits TNF, IFN-γ, reduces IL-6 and cheetification factor production, and proliferation of T-cell CD4. Animal experiments showed that the model of arthritis rats induced by the drug and the model of arthritis induced by collagen could significantly reduce joint swelling, while the inflammation of the membrane and cartilage damage were significantly improved compared to the control group. Tofatinib can reduce il-6, IL-8 levels in rat serum, reduce the invasion of cartilage by gliitis, and play an anti-inflammatory and bone protection role. In the primate allogeneic kidney transplant rejection response model, tofatinib can significantly prolong the average survival of animals and is positively correlated with the dose of administration.

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