Tofacitinib Citrate High quality 540737-29-9 High purity trader CAS NO.540737-29-9

Tofacitinib Citrate High quality 540737-29-9 High purity trader 

Tofatinib targets the jaK-STAT signal transduction pathway in cells by inhibiting JAK phosphorylation, thereby preventing STAT phosphorylation, reducing the synthesis of downstream inflammatory cytokines, thus inhibiting CD-4T cell proliferation, blocking the synthesis and secretion of a variety of inflammatory cytokines to be anti-inflammatory and regulate the role of immunity. The study found that tofatinib blocked common cytokines in the c-chain (IL-2, IL-7, IL-9, IL-15 and IL-21, etc.) that bind to JAK3, as well as the gp130 families (IL-6 and IL-11) and the type II cytokine receptor families (IFN-α/β, IFN-γ, etc.). Since the drug also has a relatively weak inhibitory effect on JAK2, it can also block the beta-C family (IL-3, IL-5, GM-CSF, EPO and IFN gamma). Therefore, tofatinib can affect the differentiation of Th1 cells and the production of pathogenic Th17 cells by blocking JAK1 and JAK2. Since tofatinib has a blocking effect on IL-21, it is also hypothesized that it could impair the function of B cells and follicle-assisted T cells (Tfh cells).

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