Tofacitinib Citrate factory supply 540737-29-9 on hot selling Reliable quality CAS NO.540737-29-9

Tofacitinib Citrate factory supply 540737-29-9 on hot selling Reliable quality

Take 10g of tofatinib crude 12g in the reaction bottle, add 125ml of dimethyl methylene, nal propylene alcohol and chloroform (volume ratio DMF: chloropropanol: chloroform : 1:2:0.5) of the mixture solvent, heating up to 85 To make it completely dissolved and insulation stirring, the solution for clarification of the liquid, add activated carbon 0.3g, continue to keep warm stirring reaction for 50 minutes, stirring speed of 30 rpm, while hot filtering, slow cooling every 10 minutes drop 4 to 5 degrees C, from 85 degrees C to 20 to 25 degrees C Every 5 minutes down 1 to 2 degrees C, from 25 degrees C to -5 to 0 degrees C, stirring crystal 12h, filtration, cake washing with mixed solvent, in 50 degrees C vacuum drying 12h product 9.87g, yield 98.7%, purity 99.93% (HPLC detection), the maximum single hem 0.06%, total miscellaneous 0.08%.

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