Entecavir in bulk supply 209216-23-9 in china in stock CAS NO.209216-23-9

Entecavir in bulk supply 209216-23-9 in china in stock 

In cell tests, it was found that the strain of lamivdin-resistant virus was 8 to 30 times less sensitive to Ntekave. If hepatitis B virus polyenzyme is inherently present in amino acid replacement (rtL180M and/or rtM204V/I), plus rtT184, rtS202 or rtM The displacement variation of 250 bits, or on the basis of the simultaneous occurrence of both variations, whether or not there is a replacement variation of rtI169, will result in a greater reduction in the apparent sensitivity to Ntekave (> 70 times). Cross-resistance: Cross-resistance has been found in nucleoside analogues of anti-hepatitis B virus, and in cell tests, Ntekave's inhibition of strains resistant to lamivdine (rtL180M and/or rtM204V/I) has been reduced by 8 to 30 times compared to wild strains. Ntikave is also fully sensitive to recombinant viruses of Adelfove resistance variants (HBVDNA polyenzyme rtN236T or rtA181V variants). In vitro tests showed that the strain isolated from patients who both failed ramifedin and Ntikawe was sensitive to Adelfovir, but remained resistant to lamivdin.

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